What is
DERBIOME® PDRN?
Our patented, low-molecular salmon DNA ingredient. Selected to support smoother, firmer-looking, more resilient skin.
PDRN
support
support
DERBIOME PDRN + MATRIXYL 3000 PEPTIDES
A daily PDRN + peptide firming serum with instrument-measured results and an elegant, fast-absorbing finish.
PDRN renewal + peptide firming for smoother, firmer-looking skin.
55% immediate, temporary elastic restoring force after one use* · 16% eye-wrinkle depth in 10 days*
90-day money-back guarantee · Free U.S. shipping $50+ after discounts
AMAZON MARKETPLACE PROOF
HOW IT WORKS
DERBIOME® PDRN supports the look of smoother, more resilient skin. Matrixyl® 3000 peptides support firmer-looking skin and visibly softened lines.
*Conceptual formula map; it does not claim penetration to a specific skin layer. Ingredient roles describe cosmetic positioning. Finished-formula clinical results appear below.
PROPRIETARY KOREAN SCIENCE
Our patented, low-molecular salmon DNA ingredient. Selected to support smoother, firmer-looking, more resilient skin.
A low-molecular PDRN system at the core of Ultra Serum’s daily firming formula.


A salmon-derived PDRN system selected to support the look of smoother, more resilient skin.
EXPLORE CISL SCIENCEFinished formula · clinical
One use for elastic restoring force. Ten days for eye-wrinkle depth.




*Independent third-party tests in women ages 40–60 (n=20 per test). Elasticity: immediate, temporary forearm result after one use. Eye-wrinkle depth: 10 days. Facial images illustrate appearance. Individual results may vary.
*Independent third-party finished-formula tests by ProbeM Skin Research Center, Korea, 2025. Eye-wrinkle test: 20 women ages 40–60, used twice daily for 10 days, measured by Antera 3D; change versus baseline, p<0.05. Elastic restoring-force test: 20 women ages 40–60, single application on the forearm, instrument measured against an untreated control; immediate and temporary result, p<0.05. The facial Before/After image illustrates appearance and is not the measurement site for the elastic restoring-force test. Individual results may vary.
Best for
Finished-formula discipline




Ultra Serum’s finished formula was evaluated in independent instrumental studies and a primary patch test. The finished formula was rated non-irritant in a primary patch test of 30 adults; sensitive or hypersensitive skin participants were excluded.
That result does not establish that every sensitive-skin user will tolerate the formula. Patch testing before full use is appropriate when skin is reactive.
Real skin · real results

Good quality and good price — I like it. It leave a glow to the skin and it is not grease. The size is as good as the price. It has good absorption and good hydration.
I like it. It leave a glow to the skin and it is not grease. The size is as good as the price. It has good absorption and good hydration.

New Holy Grail — I was hesitant to try as the brand seemed new and not much genuine reviews, but I got all 3 of their products and they are more amazing than my expectations. I have combo skin and perioraldermatitis on my chin, so my skin is pretty picky on formulas and acne prone. They absorb really well and I wake up with smooth silky skin with these products, literally lasting me almost all day with a legit nice glow without oily looking, that I dont even need to wash my face next day other than water. Didnt have any acne or closed comedones. Hope this brand gets more attention and continue their products.
I was hesitant to try as the brand seemed new and not much genuine reviews, but I got all 3 of their products and they are more amazing than my expectations. I have combo skin and perioraldermatitis on my chin, so my skin is pretty picky on formulas and acne prone. They absorb really well and I wake up with smooth silky skin with these products, literally lasting me almost all day with a legit nice glow without oily looking, that I dont even need to wash my face next day other than water. Didnt have any acne or closed comedones. Hope this brand gets more attention and continue their products.

Hydrating, lightweight serum with noticeable skin-smoothing results — This serum fits nicely into a regular skincare routine, especially if hydration and smoothing are your main goals. It has little to no scent, which I appreciate, and the texture is lightweight and easy to spread without feeling sticky or heavy afterward. It absorbs fairly quickly but still leaves skin feeling nourished and soft, and over time my skin looked a bit more even and firm. There is a mild tightening or tingly sensation at first, which didn’t bother me, but it’s something to be aware of if your skin is sensitive. The formula feels well thought out, and you don’t need much per use, so the bottle should last a while even if the price is on the higher side. I found it especially nice around the eye area and at night, since it didn’t cause irritation or dryness. The only real downside is that the labeling on the bottle is hard to read, but performance-wise it delivers a smooth, hydrated feel that makes it worth keeping in rotation.
This serum fits nicely into a regular skincare routine, especially if hydration and smoothing are your main goals. It has little to no scent, which I appreciate, and the texture is lightweight and easy to spread without feeling sticky or heavy afterward. It absorbs fairly quickly but still leaves skin feeling nourished and soft, and over time my skin looked a bit more even and firm. There is a mild tightening or tingly sensation at first, which didn’t bother me, but it’s something to be aware of if your skin is sensitive. The formula feels well thought out, and you don’t need much per use, so the bottle should last a while even if the price is on the higher side. I found it especially nice around the eye area and at night, since it didn’t cause irritation or dryness. The only real downside is that the labeling on the bottle is hard to read, but performance-wise it delivers a smooth, hydrated feel that makes it worth keeping in rotation.

Good tightening brightening serum — I have used an exosome serum before and I think they help with tightening, brightening, and skin recovery. This one seems to work really well, and has high quality ingredients such as a peptide complex, 5% pdrn, and exosomes. I believe the exosomes is what causes a slightly tingly or tightening feeling. It doesn't bother me, but keep that in mind if you are trying it. I also don't use any harsh serums or toners while using this as it can be intense on it's own. The color is a clearish blue. It's lightweight and hydrating. I think it's a little more expensive than other's I've tried for the same amount, however this has much stronger ingredients so it could be more value in the long run. You only need to use a little at a time, and I only use it a couple days a week so it will last a long time.
I have used an exosome serum before and I think they help with tightening, brightening, and skin recovery. This one seems to work really well, and has high quality ingredients such as a peptide complex, 5% pdrn, and exosomes. I believe the exosomes is what causes a slightly tingly or tightening feeling. It doesn't bother me, but keep that in mind if you are trying it. I also don't use any harsh serums or toners while using this as it can be intense on it's own. The color is a clearish blue. It's lightweight and hydrating. I think it's a little more expensive than other's I've tried for the same amount, however this has much stronger ingredients so it could be more value in the long run. You only need to use a little at a time, and I only use it a couple days a week so it will last a long time.

The best ever! — This is the BEST!!!!! Buy it NOW
Choose your treatment style
| Ultra Serum | Dual Infushot Serum | |
|---|---|---|
| Role | Daily PDRN + peptide firming | Intensive dual-chamber renewal |
| Best-fit concerns | Firming, fine lines, daily hydration | Pores, uneven texture, radiance |
| Core technology | PDRN + Matrixyl 3000 peptides | PDRN + HPR retinoid + micro-spicules |
| Routine character | Lightweight daily-serum texture | More intensive renewal format |
How to use
to face and neck, avoiding direct contact with eyes.
during the day.
Ultra Serum FAQ
Daily firming
A daily PDRN + peptide firming serum with instrument-measured results and an elegant, fast-absorbing finish.
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