DERBIOME PDRN + MATRIXYL 3000 PEPTIDES
ULTRA WRINKLE CORREXION™ SERUM
Your daily PDRN firming serum.
For face and neck routines focused on firmer-looking skin, especially when skin looks dry or tired.
PDRN + Matrixyl 3000 peptides. Explore the texture and measured results.
+55.32% temporary elastic restoring force, measured on the forearm immediately after one use
After Ultra Serum, add the optional moisturizing step · Cream
$79$63.20.
Customer feedback on AMAZON
Ultra Serum, rated by Amazon customers.
View Ultra Serum on Amazon · Rating checked Sep 30, 2026
“my skin is more firm and radiant.”
CISL SEOUL · ULTRA SERUM
A daily serum for firmer-looking skin.
Finished formula · clinical
Results you can see.
One use for elastic restoring force. Ten days for eye-wrinkle depth.
*Independent third-party tests in women ages 40–60 (n=20 per test). Elasticity: immediate, temporary forearm result after one use. Eye-wrinkle depth: 10 days. Facial images illustrate appearance. Individual results may vary.
Study details
Finished-formula tests by ProbeM Skin Research Center, Korea, 2025. Eye-wrinkle test: 20 women ages 40–60, twice-daily use for 10 days, Antera 3D measurement versus baseline, p<0.05. Elastic restoring-force test: 20 women ages 40–60, single application on the forearm, instrument measured against an untreated control; immediate and temporary result, p<0.05. The facial Before/After image is not the measurement site for elastic restoring force. Individual results may vary.
PROPRIETARY KOREAN SCIENCE
DERBIOME® PDRN
What is
DERBIOME® PDRN?
Our patented, low-molecular salmon DNA ingredient. Selected to support smoother, firmer-looking, more resilient skin.
PDRN
support
support
Small by design.
Purposefully refined.
A low-molecular PDRN system at the core of Ultra Serum’s daily firming formula.


PDRN technology at the core of Ultra Serum's daily firming approach.
A salmon-derived PDRN system selected to support the look of smoother, more resilient skin.
EXPLORE CISL SCIENCEBest for
For skin that no longer feels as firm as it used to.
- Visible loss of firmness
- Fine lines and eye-area wrinkles
- Dry or tired-looking skin
- Anyone who dislikes a heavy, sticky serum finish
Finished-formula discipline
Developed with Korean clinical discipline.




Ultra Serum’s finished formula was evaluated in independent instrumental studies and a primary patch test. The finished formula was rated non-irritant in a primary patch test of 30 adults; sensitive or hypersensitive skin participants were excluded.
That result does not establish that every sensitive-skin user will tolerate the formula. Patch testing before full use is appropriate when skin is reactive.
Real skin · real results
See what customers are saying.

Not this reviewer's photo
Good quality and good price — I like it. It leave a glow to the skin and it is not grease. The size is as good as the price. It has good absorption and good hydration.
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I like it. It leave a glow to the skin and it is not grease. The size is as good as the price. It has good absorption and good hydration.

Not this reviewer's photo
New Holy Grail — I was hesitant to try as the brand seemed new and not much genuine reviews, but I got all 3 of their products and they are more amazing than my expectations. I have combo skin and perioraldermatitis on my chin, so my skin is pretty picky on formulas and acne prone. They absorb really well and I wake up with smooth silky skin with these products, literally lasting me almost all day with a legit nice glow without oily looking, that I dont even need to wash my face next day other than water. Didnt have any acne or closed comedones. Hope this brand gets more attention and continue their products.
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I was hesitant to try as the brand seemed new and not much genuine reviews, but I got all 3 of their products and they are more amazing than my expectations. I have combo skin and perioraldermatitis on my chin, so my skin is pretty picky on formulas and acne prone. They absorb really well and I wake up with smooth silky skin with these products, literally lasting me almost all day with a legit nice glow without oily looking, that I dont even need to wash my face next day other than water. Didnt have any acne or closed comedones. Hope this brand gets more attention and continue their products.

Not this reviewer's photo
Hydrating, lightweight serum with noticeable skin-smoothing results — This serum fits nicely into a regular skincare routine, especially if hydration and smoothing are your main goals. It has little to no scent, which I appreciate, and the texture is lightweight and easy to spread without feeling sticky or heavy afterward. It absorbs fairly quickly but still leaves skin feeling nourished and soft, and over time my skin looked a bit more even and firm. There is a mild tightening or tingly sensation at first, which didn’t bother me, but it’s something to be aware of if your skin is sensitive. The formula feels well thought out, and you don’t need much per use, so the bottle should last a while even if the price is on the higher side. I found it especially nice around the eye area and at night, since it didn’t cause irritation or dryness. The only real downside is that the labeling on the bottle is hard to read, but performance-wise it delivers a smooth, hydrated feel that makes it worth keeping in rotation.
Read full review
This serum fits nicely into a regular skincare routine, especially if hydration and smoothing are your main goals. It has little to no scent, which I appreciate, and the texture is lightweight and easy to spread without feeling sticky or heavy afterward. It absorbs fairly quickly but still leaves skin feeling nourished and soft, and over time my skin looked a bit more even and firm. There is a mild tightening or tingly sensation at first, which didn’t bother me, but it’s something to be aware of if your skin is sensitive. The formula feels well thought out, and you don’t need much per use, so the bottle should last a while even if the price is on the higher side. I found it especially nice around the eye area and at night, since it didn’t cause irritation or dryness. The only real downside is that the labeling on the bottle is hard to read, but performance-wise it delivers a smooth, hydrated feel that makes it worth keeping in rotation.

Not this reviewer's photo
Good tightening brightening serum — I have used an exosome serum before and I think they help with tightening, brightening, and skin recovery. This one seems to work really well, and has high quality ingredients such as a peptide complex, 5% pdrn, and exosomes. I believe the exosomes is what causes a slightly tingly or tightening feeling. It doesn't bother me, but keep that in mind if you are trying it. I also don't use any harsh serums or toners while using this as it can be intense on it's own. The color is a clearish blue. It's lightweight and hydrating. I think it's a little more expensive than other's I've tried for the same amount, however this has much stronger ingredients so it could be more value in the long run. You only need to use a little at a time, and I only use it a couple days a week so it will last a long time.
Read full review
I have used an exosome serum before and I think they help with tightening, brightening, and skin recovery. This one seems to work really well, and has high quality ingredients such as a peptide complex, 5% pdrn, and exosomes. I believe the exosomes is what causes a slightly tingly or tightening feeling. It doesn't bother me, but keep that in mind if you are trying it. I also don't use any harsh serums or toners while using this as it can be intense on it's own. The color is a clearish blue. It's lightweight and hydrating. I think it's a little more expensive than other's I've tried for the same amount, however this has much stronger ingredients so it could be more value in the long run. You only need to use a little at a time, and I only use it a couple days a week so it will last a long time.

Not this reviewer's photo
The best ever! — This is the BEST!!!!! Buy it NOW
Choose your treatment style
Ultra for daily firming. Dual for intensive renewal.
| Ultra Serum | Dual Infushot Serum | |
|---|---|---|
| Role | Daily PDRN + peptide firming | Intensive dual-chamber renewal |
| Best-fit concerns | Firming, fine lines, daily hydration | Pores, uneven texture, radiance |
| Core technology | PDRN + Matrixyl 3000 peptides | PDRN + HPR retinoid + micro-spicules |
| Routine character | Lightweight daily-serum texture | More intensive renewal format |
How to use
Drop. Press. Smooth.
to face and neck, avoiding direct contact with eyes.
during the day.
Ultra Serum FAQ
Questions, answered.
What is PDRN, and where is it sourced?
What does Matrixyl 3000 do in this formula?
When can I expect visible results?
What does the 16% clinical result measure?
What does the 55% result mean?
Can I use it around the eye area?
Is it suitable for sensitive skin?
How is Ultra different from Dual Infushot Serum?
What is covered by the 90-day guarantee?
Daily firming
Make firming a daily habit.
A daily PDRN + peptide firming serum with instrument-measured results and an elegant, fast-absorbing finish.
90-DAY MONEY-BACK GUARANTEE · FREE U.S. SHIPPING $50+ AFTER DISCOUNTS
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