DERBIOME PDRN + MATRIXYL 3000 PEPTIDES

ULTRA WRINKLE CORREXION™ SERUM

★★★★★4.8 · 65 reviews

A daily PDRN + peptide firming serum with instrument-measured results and an elegant, fast-absorbing finish.

PDRN renewal + peptide firming for smoother, firmer-looking skin.

$69· 30 mL / 1.0 fl oz

55% immediate, temporary elastic restoring force after one use* · 16% eye-wrinkle depth in 10 days*

90-day money-back guarantee · Free U.S. shipping $50+ after discounts

ULTRA WRINKLE CORREXION™...$69

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HOW IT WORKS

PDRN FOR SKIN QUALITY.
PEPTIDES FOR FIRMNESS.

DERBIOME® PDRN supports the look of smoother, more resilient skin. Matrixyl® 3000 peptides support firmer-looking skin and visibly softened lines.

Mature woman holding CISL Ultra Serum
Skin structure illustration showing epidermis, dermis, collagen network, Matrixyl 3000, PDRN and exosomes

*Conceptual formula map; it does not claim penetration to a specific skin layer. Ingredient roles describe cosmetic positioning. Finished-formula clinical results appear below.

PROPRIETARY KOREAN SCIENCE

DERBIOME® PDRN

Clinic-inspired Korean skin science

What is
DERBIOME® PDRN?

Our patented, low-molecular salmon DNA ingredient. Selected to support smoother, firmer-looking, more resilient skin.

Salmon-derived
PDRN
Skin renewal
support
Skin resilience
support
Advanced low-molecular technology

Small by design.
Purposefully refined.

A low-molecular PDRN system at the core of Ultra Serum’s daily firming formula.

DERBIOME® PDRN
Small molecule illustration
Low-molecular design
Conventional PDRN
Larger molecule illustration
Larger molecular profile
01 / 03

PDRN technology at the core of Ultra Serum's daily firming approach.

A salmon-derived PDRN system selected to support the look of smoother, more resilient skin.

EXPLORE CISL SCIENCE

Finished formula · clinical

Results you can see.

One use for elastic restoring force. Ten days for eye-wrinkle depth.

Before Ultra Serum useAfter Ultra Serum use — illustrative facial appearance
55.3%Elastic restoring forceImmediate + temporary · after one use
Before Ultra Serum useAfter ten days of Ultra Serum use
16.1%Eye-wrinkle depth improvementAfter 10 days

*Independent third-party tests in women ages 40–60 (n=20 per test). Elasticity: immediate, temporary forearm result after one use. Eye-wrinkle depth: 10 days. Facial images illustrate appearance. Individual results may vary.

Study details

*Independent third-party finished-formula tests by ProbeM Skin Research Center, Korea, 2025. Eye-wrinkle test: 20 women ages 40–60, used twice daily for 10 days, measured by Antera 3D; change versus baseline, p<0.05. Elastic restoring-force test: 20 women ages 40–60, single application on the forearm, instrument measured against an untreated control; immediate and temporary result, p<0.05. The facial Before/After image illustrates appearance and is not the measurement site for the elastic restoring-force test. Individual results may vary.

Best for

For skin that no longer feels as firm as it used to.

  • Visible loss of firmness
  • Fine lines and eye-area wrinkles
  • Dry or tired-looking skin
  • Anyone who dislikes a heavy, sticky serum finish

Finished-formula discipline

Developed with Korean clinical discipline.

Dr. Donghyun Youn portrait
Dr. Donghyun Youn preparing for a clinical procedure
Dr. Donghyun Youn performing a clinical treatment
Dr. Donghyun Youn consulting with a patient

Ultra Serum’s finished formula was evaluated in independent instrumental studies and a primary patch test. The finished formula was rated non-irritant in a primary patch test of 30 adults; sensitive or hypersensitive skin participants were excluded.

That result does not establish that every sensitive-skin user will tolerate the formula. Patch testing before full use is appropriate when skin is reactive.

Real skin · real results

See what customers are saying.

Choose your treatment style

Ultra for daily firming. Dual for intensive renewal.

Ultra SerumDual Infushot Serum
RoleDaily PDRN + peptide firmingIntensive dual-chamber renewal
Best-fit concernsFirming, fine lines, daily hydrationPores, uneven texture, radiance
Core technologyPDRN + Matrixyl 3000 peptidesPDRN + HPR retinoid + micro-spicules
Routine characterLightweight daily-serum textureMore intensive renewal format

How to use

Drop. Press. Smooth.

Cleanse and tone.
Apply 2–3 drops

to face and neck, avoiding direct contact with eyes.

Follow with moisturizer.
Use sunscreen

during the day.

Ultra Serum FAQ

Questions, answered.

What is PDRN, and where is it sourced?
Ultra uses a salmon-derived PDRN system selected to support the look of smoother, more resilient skin.
What does Matrixyl 3000 do in this formula?
Matrixyl 3000 is a peptide complex used to support firmer-looking skin and visibly softened lines.
When can I expect visible results?
The finished-formula eye-wrinkle study measured improvement after 10 days. A separate elastic restoring-force study measured an immediate, temporary result after one use. Individual results vary.
What does the 16% clinical result measure?
It refers to a 16.1% improvement in instrument-measured eye-wrinkle depth after 10 days of twice-daily use in a 20-woman study, measured by Antera 3D versus baseline.
What does the 55% result mean?
It refers to a 55.3% improvement in immediate, temporary skin elastic restoring force after a single application, instrument measured on the forearm against an untreated control. It is not a 10-day elasticity claim.
Can I use it around the eye area?
The eye-wrinkle study evaluated the eye area. For normal use, apply to the surrounding facial skin while avoiding direct contact with the eyes.
Is it suitable for sensitive skin?
The finished formula was rated non-irritant in a primary patch test of 30 adults. Sensitive or hypersensitive skin participants were excluded, so individual tolerance can vary. Patch test before full use if your skin is reactive.
How is Ultra different from Dual Infushot Serum?
Ultra is positioned as daily PDRN + peptide firming for firmness, fine lines, and hydration. Dual is a more intensive dual-chamber renewal serum with a different technology and use profile.
What is covered by the 90-day guarantee?
The full-size product is presented with a 90-day money-back guarantee. The current CISL SEOUL refund policy contains the governing terms.

Daily firming

Make firming a daily habit.

A daily PDRN + peptide firming serum with instrument-measured results and an elegant, fast-absorbing finish.

ONE-TIME PURCHASE
$69
30 mL / 1.0 fl oz
SUBSCRIBE & SAVE 15%
$58.65
Deliver every 2 months, 15% off

90-DAY MONEY-BACK GUARANTEE · FREE U.S. SHIPPING $50+ AFTER DISCOUNTS

VIEW REFUND POLICY
  • 5 stars: 53 (82%)
  • 4 stars: 9 (14%)
  • 3 stars: 2 (3%)
  • 2 stars: 1 (2%)
  • 1 star: 0 (0%)
L
Lisa L.
Simple & effective

Lightweight, fast-absorbing serum. I’m using it as a preventative anti-aging step, and my skin texture looks smoother and more refined. It also feels like a much more expensive product for the price.

H
Hannah s.
Feels smooth and lightweight

Skin feels smoother, softer, and more hydrated after using it. It layers well with the rest of my routine and doesn’t feel heavy. Feels like a well-formulated anti-aging serum.

V
Vernesse
So happy I found this brand

Really happy this brand launched, I’ve been using the Wrinkle Serum for a few weeks and I can honestly see my skin looking smoother and a bit fresher. The texture feels great and absorbs so well. I’ve already re-purchased it because it’s become one of my favorites

C
Claire H.
Softer Lines

My forehead lines have softened a lot after 3 weeks, it’s not Botox, but it works. The texture is silky and layers well under moisturizer.

F
Fbakare

Extremely high product efficacy I would highly recommend!

S
Sheena B.

I've been using the Ultra Wrinkle Correxion Serum as a preventative measure against wrinkles and aging skin. In just a short time, I've noticed that my skin is more firm and radiant. I'm encouraged by the results and will continue to see how this product will continue to benefit me.

A
Amaia R.
Using this between treatments

I originally picked this serum up to support my skin alongside my regular injectable treatments. After using it consistently for a few weeks, I started noticing my skin looked smoother and more firm on its own. At my last appointment, my injector mentioned that my skin looked great and that I didn't really need much done. My fine lines look softer, my skin fels healthier, and I've been able to push my appointments further paart. I didn't expect a topical serum to make this kind of difference, but I'm genuinely impressed.

C
Carla M.
Great formula

Most wrinkle serums don’t disclose meaningful percentages, so I was impressed to see 10% peptides and 5% PDRN. My skin looks more refined and feels firmer after a few weeks of use. Gentle but effective.

L
Lara S.
Yes, it works!

Tried so many serums, some made my skin dry or red. This one feels smooth, lightweight, and effective on my fine lines. Skin looks more alive now

J
Jamie L.
Bought this as a gift

Got this for my wife after she loved the Dual Serum I gave her for Christmas. She’s been using that one every day and keeps saying how smooth and hydrated her skin feels.

With Valentine’s Day coming up, I wanted to get her something else from the same brand since she had such a good experience before. Felt like a safe bet. Definitely recommend this brand.

A
Amber R.
Gentle on sensitive skin

I have sensitive skin and I’m very careful with wrinkle serums, but this felt comfortable from the very first use. No stinging, no redness, no irritation. My skin feels calmer, more balanced, and noticeably smoother. After around 10 days, my skin looked more radiant and my eye area felt firmer. It gives me confidence that I’m supporting my skin barrier while also addressing fine lines.

V
Vernesse H.
My skin looks healthier and smoother

I always had good skin (so lucky!), but as I've gotten older, my skin became drier, more sensitive, and just looked tired. I started looking for something that could help with fine lines and overall skin quality without irritating my skin.
I decided to try this Ultra Wrinkle serum because of the high percentage of Matrixyl 3000 and the additional of PDRN, and I'm so glad I did. My skin looks smoother, feels firmer, and has a healthier glow. It absorbs well, isn't sticky, and hasn't caused any irrtation at all.
My skin honestly looks better than it has in a long time. This one is staying in my routine.

L
Louise J.
Perfect for dry, sensitive type of skin

I have very dry and sesitive skin, and this serum has been great for me. It feels slightly thicker than some serums, but it absrobs well and leaves my skin feeling soft, hydrated, and comfortable.
After a couple of weeks, I noticed my skin looked smoother and more even, especially around my mouth and eyes. I love taht it focuses on peptides and PDRN instead of harsh actives.
No scent, no irritation and my skin looks healthier. Definetely recommend.

D
Danielle K.
My skin drinks this up!

My skin drinks this up. It absorbs fast, isn't greasy, and leaves my skin feeling plump and smooth.
I use it every morning and night, and it's become my go-to wrinkle serum. I've started noticing my skin feels firmer and makeup sits better on top. The dropper makes it easy to use the right amount, and I appreciate that's fragance-free.

R
Rosa S.
Good for sensitive skin

My face is very sensitive and this serum feels great on my skin. No stinging and no redness.

J
Judy K.
Nice Texture, Still Testing

I bought this serum because I was interested in the Matrixyl 3000 and PDRN combination. The bottle is nice, the texture feels good, and it absorbs well without feeling sticky.

I’ve been using it once a day and haven’t seen a dramatic difference yet, but my skin does feel smoother and hydrated. I’ll continue using it to see if results improve over time.

I’ve liked other products from this brand, so I’m hopeful.

D
Donna S.
Impressed so far

I wanted to try it because it contains PDRN and Matrixyl, which you usually find in more expensive products. I'm impressed! Very good texture, no smell, and easy to absorb, it's perfect for night use. I really love it!

S
Susie B.
Hydrates well & good brand

I absolutely love this serum. It hydrates really well and leaves my skin feeling soft and smooth. I like that it focuses on peptides and PDRN instead of harsh actives, and it feels gentle on my skin.

I’ve been very happy with this brand overall, and this serum fits perfectly into my routine. Definitely one of my favorite skincare lines.

T
Thomas E.
Easy gift win!

I bought the CISL Seoul Ultra Serum for my partner after one of her friends recommended it. She’s been in love with it ever since.

Now I’m basically working my way through their other products because I know she’ll use them. Honestly, such a safe bet.

If you’re ever struggling with gift ideas, a Korean clinic-inspired skincare brand like this is an easy win.

M
Matilda P.
Great for Mature Skin

Menopause completely changed my skin texture and moisture level. I was struggling with dryness and dullness, and many products irritated my skin.

This serum feels soothing and lightweight, and it hasn’t caused any irritation. My skin looks more supple and feels firmer, especially around my cheeks and jawline. Very happy I tried this.

R
Regina T.
Injector perspective

From a clinical standpoint, I like products that focus on skin quality and barrier health. This serum’s peptide concentration plus PDRN is a strong combination. I’ve noticed improvement in texture, firmness, and overall skin appearance.

A
Adriana M.
Impressive ingredient levels

I pay close attention to formulations, and it’s rare to see a serum with 10% Matrixyl 3000 and 5% PDRN in one product. After using this consistently, my skin feels firmer, smoother, and more resilient. The ingredient combination makes sense, and the results back it up.

B
Brook T.
Fav for daily use

I used to switch between different brands each month. This one I actually stuck with — skin looks firmer and fine lines softer.

H
Harper I.
Noticed improvement

Only about 10 days in and my skin already feels smoother and looks more refined. Happy so far.

Z
Zoe C.
Love how it feels

I’ve experimented with many wrinkle serums at different price points, and most of them either irritated my skin or felt too heavy. This serum feels gentle, hydrating, and absorbs quickly. My skin looks smoother, feels firmer, and overall looks healthier. It’s one of the few serums I actually enjoy using every day.

J
Jupiter S.
Love this serum

Whenever my wife really likes a skincare product she makes sure to tell me all about it, and that is exactly what happened here. She said she could actually feel and see a difference after using this serum, which immediately put it in the win column for her. She found it effective and liked how her skin felt while using it. The only downside is that the bottle itself is hard to read because of the font color choices, so make sure you read the box before tossing it. Aside from that minor issue, this is a high quality product that clearly delivered results for her. 

M
Mona S.
Skin feels softer and smoother

This gives an added boost of hydration which is extra helpful for me during the cold winters when my skin tends to dry out even more. This is a great added benefit for someone like me in need of as much hydration as possible. I really like that this is a liquidy-type serum and not a thicker almost lotion-type serum. This serum goes on easy and little goes a long way, so there's good value for the size and money. There is no sticky residue and absorbs fast, so this makes it easy to use in layer fashion as I add my moisturizer after. I'm new to using PDRN and Matrixyl products but I find that they work well, 

H
Hannah D.
Great replacement for my old serum

I used to use Depology’s anti-aging serum and liked it at first, but over time I felt like my skin needed something more hydrating and comfortable. After switching to this serum, my skin feels noticeably smoother and more nourished. My fine lines look softer, and my overall skin texture looks more even. It also absorbs better and doesn’t leave any sticky feeling. I’m really happy with the switch.

M
Megan W.
Obsessed with this

I switched from a pricier Obagi serum and this works just as well for fine lines and firmness. Bonus: no irritation.